CellSpace brings together corporates, higher education and research institutions and public institutions in Southern Paris. The association is led by personalities justifying a long medical experience. These energies and skills undertake the project for the construction of an international platform specializing in regenerative medicine and bioengineered organs.
Agence de développement du Val-de-Marne
BIOPREDIC International provides human and animal tissues, cells, fractions and reagents such as hepatocytes and other derivatives of the liver, skin products, blood products and other biological fluids and non-standard animal products. These reagents are used for in vitro tests in pharmaceutical, cosmetic and chemical industry. BIOPREDIC International holds a portfolio of patents and licenses on the human liver cell line HepaRG®.
CELLforCURE is a subsidiary of LFB pharmaceutical Group. Located near Paris, CELLforCURE industrializes the manufacturing of cell and gene therapy medicinal products, for clinical phases and the market in a GMP frame conform to both American and European requirements.
Cellenion is a start-up company offering solutions and technologies for controlled cell dispensing with applications in the fields of bioprinting and single-cell isolation. Bioprinting is the process of generating spatially-controlled cell patterns using 3D printing technologies. Cellenion is aiming toward both miniaturization and automation in order to produce reproducible 3D in vitro models of different complexities. Ability to manipulate single-cell has long been a challenge for the scientific community due to their micrometric size and delicate nature. Cellenion has developed and patented a breakthrough technology called CellenONE allowing high throughput isolation and dispensing of single-cell onto a wide range of substrates. This opens new opportunities in the booming field of single-cell analytics and the development and selection of novel cell lines (e.g. in mAb development).
Université de Technologie Compiègne
The VSB territory Board associates all local authorities partners of CellSpace. Inside the Great Paris Community, they promote the layout of a major site whose aim is to develop research and innovation in health field around the « Campus Grand Parc ».
CellSpace brings together personalities performing important functions within their institutions, all heavily involved in regenerative medicine.
The Health Science hub of Southern Paris gathers transplantation centers which, in their specialties, are among the largest in France and in Europe for the number of transplants performed annually, for the monitoring of cohorts and for basic research. These centers are therefore particularly concerned by the production of bioengineered organs.
The medical teams of the university hospitals «Liver, Digestive and Urinary Diseases » and «Thorax» have a strong oncology activity involving wide surgical resections leading to complex reconstructions. The surgical team of Centre Chirurgical Marie-Lannelongue is already tracheal reconstructions.
L’Institut de Recherche Biomédicale des Armées (IRBA) conducts operational medical research on tissue repair after war injuries. Similarly, the serious burn victim unit of Percy Hospital and the restorative surgery teams of the Military Health Service take charge of patients with severe war trauma and, increasingly, will need bespoke tissues.
The research platform of the Paul-Brousse Hospital and its environment – CEA, ENS Cachan, Génopôle, Ingestem – have a large number of teams involved in research on stem cells (multipotent and pluripotent embryonic stem cells, induced puripotent stem cells) and their differentiation in mature and specialized stem cells.
Université de Technologie Compiègne (UTC) has been working for several years with the Hepatobiliary Centre of the Paul-Brousse Hospital on the design of a bio-artificial external liver. Therefore it masters many aspects of the construction of artificial organs.
The scientific environment of the new University of Paris-Saclay is particularly rich in training and research in technology, including the construction of artificial tissues and additive manufacturing.